Nucleosome-Remodeling Factor Complex (NURF): A Potential Drug Target and Biomarker

Target Name: Nucleosome-remodeling factor complex (NURF)

NCBI ID: P28884

Nucleosome-remodeling factor complex (NURF)

Other Name(s): None

Nucleosome-Remodeling Factor Complex (NURF): A Potential Drug Target and Biomarker

Introduction

Nucleosome-remodeling factor complex (NURF) is a protein that plays a critical role in maintaining the structural integrity of chromatin during the cell cycle. NURF helps to ensure that the DNA double helix remains in a stable and compact state, which ensures the proper expression of genes during the cell cycle. The NURF complex is composed of several subunits that work together to perform various functions, including the regulation of chromatin remodeling, DNA damage repair, and checkpoint signaling.

Despite its importance in cell biology, NURF is not well understood, and its functions and interactions with other proteins are still being explored. In recent years, researchers have identified several potential drug targets that interact with NURF, suggesting that NURF may be a promising biomarker and drug target in various diseases. In this article, we will discuss the current understanding of NURF, its potential drug targets, and its potential as a biomarker for various diseases.

Potential Drug Targets

NURF has been identified as a potential drug target due to its involvement in various cellular processes that are crucial for human health. Several studies have identified potential drug targets that interact with NURF. These include:

1. p53 Inhibitors: Many studies have shown that NURF can interact with the p53 protein, which is a well-known tumor suppressor gene. NURF has been shown to regulate the activity of p53, which is involved in various cellular processes, including DNA damage repair and apoptosis. p53 inhibitors have been shown to have therapeutic effects in various diseases, including cancer.
2. DNA Damage Repair: NURF is involved in the regulation of DNA damage repair, which is a critical process that helps to prevent genetic mutations that can lead to diseases. Several studies have shown that NURF can interact with DNA repair factors, including the protein DNA polymerase II.
3. Chromatin remodeling: NURF is involved in the regulation of chromatin remodeling, which is a critical process that helps to ensure the proper expression of genes during the cell cycle. Several studies have shown that NURF can interact with other chromatin remodeling factors, including the protein histone L1.

Potential Biomarkers

NURF has also been identified as a potential biomarker due to its involvement in various cellular processes that are crucial for human health. Several studies have shown that NURF can be used as a biomarker for various diseases, including cancer.

1. Cancer: Several studies have shown that NURF can be used as a biomarker for cancer. For example, one study showed that overexpression of NURF was associated with poor prognosis in breast cancer. Another study also showed that NURF was overexpressed in various types of cancer, including lung cancer, suggesting that it may be a useful biomarker for cancer detection and treatment.
2. Inflammatory diseases: NURF has been shown to be involved in the regulation of inflammation, which is a critical process that helps to maintain human health. Several studies have shown that NURF can interact with other inflammation-related proteins, including the protein Nuclear factor kappa B.

Conclusion

In conclusion, NURF is a protein that plays a critical role in maintaining the structural integrity of chromatin during the cell cycle. Despite its importance in cell biology, NURF is not well understood, and its functions and interactions with other proteins are still being explored. The potential drug targets and biomarkers identified for NURF suggest that it may be a promising area for future research. Further studies are needed to fully understand the role of NURF in

Protein Name: Nucleosome-remodeling Factor Complex (NURF)

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